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Program

Thursday, September 20, 2018

08:00 - 12:00 Registration

09:00 - 09:20

Opening remarks & Welcome addresses

Prof. Dr. Gabriele Sadowski, Prorector Research, TU Dortmund University

Prof. Dr. Dr. Oliver Kayser, Vice-President, Society for Medicinal Plant and Natural Product Research (GA)

Organization Committee

Keynote Lecture I

09:20 - 10:00

Prof. Dr. Martin Grininger, Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt

Engineering fatty acid synthases (FAS) for custom compound synthesis 

Session I: Natural Product Biosynthesis

10:00 - 10:20

Prof. Dr. Leonard Kaysser, Department of Pharmaceutical Biology, University of Tuebingen

Unusual features in the biosynthesis of β-lactone proteasome inhibitors 

10:20 - 10:40

Prof. Dr. Till F. Schäberle, Institute for Insect Biotechnology, Justus-Liebig-University of Giessen

Alkaloid biosynthesis by marine bacteria 

10:40 - 11:10

COFFEE BREAK

Session II: From Genomics to Drug Development

11:10 - 11:30

Prof. Dr. Jörn Kalinowski, Center for Biotechnology (CeBiTec), University of Bielefeld

Application of Modern Sequencing

Technologies to Natural Product Discovery and Analysis

11:30 - 11:50

Dr. Charles M. Moore, Global Discovery Chemistry, Novartis Institute for Biomedical Research, Basel

Towards a synthetic biology platform for natural product discovery 

11:50- 12:10

Dr. Andreas Brunschweiger, Faculty of Chemistry and Chemical biology, TU Dortmund University

Genetically tagged small molecule libraries

12:10- 14:00 LUNCH
Keynote Lecture II

14:00 – 14:40

Prof. Dr. Tilmann Weber, The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby

Integration of informatics and metabolic engineering for the discovery and analysis of natural products 

Session III: Pathway Reconstitution & Metabolic Engineering

14:40 – 15:00 

Prof. Dr. Frank Schulz, Faculty of Chemistry and Biochemistry, Ruhr-University Bochum

An enzymatic total synthesis of sesquiterpenes 

15:00 – 15:20 

Dr. Anna Kohl, Institute for Molecular Biotechnology, RWTH Aachen

Metabolic engineering for monolignol production in Escherichia coli 

15:20 – 15:40 

Dr. Jan Marienhagen, Institute of Bio- and Geosciences (IBG), Forschungszentrum Jülich

Microbial production of plant polyphenols with Corynebacterium glutamicum 

15:40 – 17:00

COFFEE BREAK & POSTER EXHIBITION 

Keynote Lecture III

17:00 - 17:40

Prof. Dr. Dr. Birger Lindberg Møller, Plant Biochemistry Laboratory, Center for Synthetic Biology, University of Copenhagen

P450 driven production of plant natural products 

Session IV: Redirecting Plant Biosynthesis 

17:40 - 18:00

Dr. Jakob Franke, Center of Biomolecular Drug Research (BMWZ), Leibniz University Hannover

Developing a plant-based withanolide synthetic biology platform 

18:00 - 18:20

Dr. Felix Stehle, Laboratory of Technical Biochemistry, Department of Biochemical and Chemical Engineering, TU Dortmund University

Deciphering the effect of phytohormones and microRNAs in glandular trichome development and distribution 

19:00 - 21:00

DINNER

Friday, September 21, 2018

Keynote Lecture IV 

09:00 – 09:40 

Prof. Dr. Jason Micklefield, School of Chemistry and Manchester Institute of Biotechnology, The University of Manchester

Diversification of natural and non-natural products using engineered biosynthetic pathways and enzymes 

Session V: Pathway Engineering 

09:40 – 10:00 

Prof. Dr. Matthias Brock, School of Life Sciences, University of Nottingham 

One enzyme, two products: Recombinant production of NRPS-like enzymes in fungal expression platforms 

10:00 – 10:20 

Prof. Dr. Frank Hahn, Department of Chemistry, University of Bayreuth 

In vitro studies on biosynthetic key enzymes and their applicability for chemoenzymatic synthesis 

10:20 – 10:50 

COFFEE BREAK 

Keynote Lecture V 

10:50 – 11:30 

Prof. Dr. Frank Hollmann, Department of Biotechnology, Delft University of Technology 

Are peroxygenases the new P450s? 

Scope and current challenges of peroxygenases for selective oxyfunctionalisation chemistry 

Session VI: Biocatalysis 

11:30 – 11:50 

Prof. Dr. Tanja Gulder, Department of Chemistry and Catalysis Research Center, Technical University Munich 

Effectively combining biocatalysis and photochemistry: green and mild C,C-functionalizations 

11:50 – 12:10 

Dr. Silja Mordhorst, Department of Pharmaceutical and Medicinal Chemistry, Albert-Ludwigs-University Freiburg 

Modular enzyme systems for cofactor regeneration 

12:10 – 12:30 

Dr. Katrin Rosenthal, Laboratory of Bioprocess Engineering, Department of Biochemical and Chemical Engineering, TU Dortmund University 

Enzymatic synthesis of cyclic dinucleotides 

12:30 – 12:45 

POSTER AWARDS & CLOSING REMARKS 

12:45 

END OF SYMPOSIUM